Niko Bellic (Grand Theft Auto IV) & Poison (Street Fighter)
Cortana (Halo: Series) & GlaDOS (Portal: Series)
Nothing like a little Robot/AI phantasy
Aku Aku (Crash Bandicoot: Series) & Companion Cube (Portal)
…Who says inanimate objects can’t mate?
Chuck Greene (Dead Rising 2) & Juliet Starling (Lollipop Chainsaw)
Kirby (Kirby: Series) & Boo (Super Mario: Series)
Teemo (League of Legends) & Tristana (League of Legends)
Akali (League of Legends) & Lux (League of Legends) … *sigh* Lesbians
Gum (Jet Set Radio Future) & Tony Hawk (Pro Skater)
Marcus Fenix (Gears of War: Series) & Jane Shepard (Mass Effect: Series)
Faith (Mirror’s Edge) & Sam Fisher (Splinter Cell: Series)
Yoshi & Birdo
Birdo is a Male.
Ivy (Soul Calibur 4) & Snake (Metal Gear Solid 4)